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1965 DOI: 10.1021/ja01079a026 “The structure of batrachotoxinin A, a novel steroidal alkaloid from [2] [2] According to early explorers of South America, paralysis was so immediate that birds hit with blow darts containing batrachotoxin drop out of the air. Du Bois .Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.Manuel de Lera Ruiz and Richard L. Kraus .Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.Valerie C. Clark, Liva Harinantenaina, Martin Zeller, William Ronto, James Rocca, Aaron T. Dossey, Daniel Rakotondravony, David G. I. Kingston, and Chris Shaw .An Endogenous Bile Acid and Dietary Sucrose from Skin Secretions of Alkaloid-Sequestering Poison Frogs.Stephen N. Greszler, Holly A. Reichard, and Glenn C. Micalizio .Asymmetric Synthesis of Dihydroindanes by Convergent Alkoxide-Directed Metallacycle-Mediated Bond Formation.Guido F. Pauli, J. Brent Friesen, Tanja Gödecke, Norman R. Farnsworth and Bernhard Glodny.Occurrence of Progesterone and Related Animal Steroids in Two Higher Plants,.Ken-ichi Takao,, Ryosuke Munakata, and.Recent Advances in Natural Product Synthesis by Using Intramolecular Diels−Alder Reactions.Michio Kurosu,, Lawrence R. Marcin,, Timothy J. Grinsteiner, and.Total Synthesis of (±)-Batrachotoxinin A.Takashi Tokuyama, J. Daly, and B. Witkop.Structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologs.Frederick A. Fuhrman, Geraldine J. Fuhrman, David L. Dull, Harry S. Mosher.Journal of Agricultural and Food Chemistry.Takashi Tokuyama, John Daly, B. Witkop, Isabella L. Karle, J. Karle.The structure of batrachotoxinin A, a novel steroidal alkaloid from the Columbian arrow poison frog, Phyllobates aurotaenia.Kenny M. Van Theemsche, Dieter V. Van de Sande, Dirk J. Snyders, Alain J. Labro.Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels.Eun Chae Son, Jiseon Lee, Sung-Gon Kim.Base-Promoted Cycloaddition of γ-Hydroxy- and δ-Hydroxy-α,β-Unsaturated Carbonyls with Azaoxyallyl Cations: Rapid Synthesis of Batrachotoxin was and still is used primarily for hunting by indigenous peoples of South America, especially in Colombia, but there are records of batrachotoxin being used in tribal warfare. 237.
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T. Grütter, C. Pascual, H. Wehrli.Steroide und Sexualhormone. developed a chemical synthesis of this molecule, denoted (−)-BTX, by taking advantage of a tin hydride–mediated radical cyclization to stitch together the polycyclic framework. Model studies for the total synthesis of complex cardenolides..John W. Daly, H. Martin Garraffo, Thomas F. Spande.60 Jahre Steroid-Chemie inHelvetica Chimica Acta.Edson X. Albuquerque, John W. Daly, Jordan E. Warnick.Macromolecular Sites for Specific Neurotoxins and Drugs on Chemosensitive Synapses and Electrical Excitation in Biological Membranes.Tetrodotoxin, Tarichatoxin, and Chiriquitoxin: Historical Perspectives.Annals of the New York Academy of Sciences.A hypothesis for the mechanism of sodium channel opening by batrachotoxin and related toxins.Mass spectrometry of amino steroids and steroidal alkaloids.Alkaloids of Neotropical Poison Frogs (Dendrobatidae).David J. Bower, Reinhold J. Hart, Peter A. Matthews, Merlin E. H. Howden.V.
The Active Principle of the Colombian Arrow Poison Frog, Phyllobates bicolor.Robert A. Craig, II, Catherine E. Garrison, Phuong T. Nguyen, Vladimir Yarov-Yarovoy.Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels.Tatsuya Toma, Matthew M. Logan, Frederic Menard, A. Sloan Devlin, and J.
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Find more information on.This article is cited by Batrachotoxin, a poison arrow toxin component, was isolated from the skin of a frog. -Heterocycles.April L. Lukowski, Alison R. H. Narayan.Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology.Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Marcel P. Goldschen-Ohm, Rachelle Gaudet, Denis B. Tikhonov, Boris S. Zhorov, Robert J. French.Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels.Roberto Márquez, Valeria Ramírez‐Castañeda, Adolfo Amézquita.Does batrachotoxin autoresistance coevolve with toxicity in A function of structure.
Phyllobates The batrachotoxin increases the permeability of [3] Mitteilung [1]. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Imhof, E. Gössinger, Walter Graf, L. Berner-Fenz, H. Berner, R. Schaufelberger, Heinrich Wehrli.Steroide und Sexualhormone.
How big are the frogs? Phyllobates Aurotaenia.Angewandte Chemie International Edition in English.H.
Batrachotoxin: Chemistry and Pharmacology This novel steroidal alkaloid is a valuable tool for studying ion transport in electrogenic membranes. Die Synthese von 5βO,19N-Ep (oxyäthanoimino)-Steroiden.The Chemistry of Nonhormonal Interactions: Terpenoid Compounds in Ecology.Chemie und Biochemie von Amphibiengaiften.Jeffrey Shindelman, Harry S. Mosher, Frederick A. Fuhrman.Atelopidtoxin from the Panamanian frog, Atelopus zeteki.Mass Spectrometry of Selected Natural Products.Your Mendeley pairing has expired. Soc. How does the toxin work? Die Partialsynthese von Batrachotoxinin A.Chemistry and Pharmacology of Frog Venoms.Batrachotoxin, an Extremely Active Cardio- and Neurotoxin from the Colombian Arrow Poison Frog P. Dumbacher, A. Wako, S. R. Derrickson, A. Samuelson, T. F. Spande, J. W. Daly.Melyrid beetles (Choresine): A putative source for the batrachotoxin alkaloids found in poison-dart frogs and toxic passerine birds.Proceedings of the National Academy of Sciences.Osamu Hoshino, Masatoshi Murakata, Miyuki Ishizaki, Tetsuji Kametani, Toshio Honda, Keiichiro Fukumoto, Masataka Ihara.John W. Daly, H. Martin Garraffo, Thomas F. Spande.Synthetic studies towards batrachotoxin 1. DOI: 10.3109/15563657108990484.
Berner, Frau L. Berner-Fenz, R. Binder, W. Graf, Frl. VII. In addition, there are many examples of alkaloids of microbial, marine, and human origin, including a vast array of nitrogen-containing antibiotics.
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