LD50 in dogs is >0.2 mg/kg. Do not induce vomiting or … Gastric lavage (flushing/rinsing of the stomach) and the administration of intravenous fluids are recommended. "The convulsions are often triggered by stimuli – when your body senses something, neurons want to fire, and if they aren’t controlled seizures occur – so patients are generally kept in quiet, dark rooms." Uncontrolled violent seizures (sometimes in response to bright lights or noise) 5. The highest concentrations of strychnine are found in the blood, liver, and kidneys. It has been used as a rodenticide since the 1500’s as well as for various antiquated medical treatments. In cats, the LD50 is >0.5 mg/kg. Anticonvulsants such as There is no specific antidote for strychnine. Strychnine is ionized in an acidic pH and then rapidly and completely absorbed in the small intestine. While strychnine is supposed to be used below-ground (e.g., buried), it is sometimes used to maliciously poison dogs. Elevated heart rate 7. High body temperature 8. Severe spasms leading to arching of the head, neck and back in extreme hyperextension(opisthotonus) 4. Depending on the quantity ingested and treatment measures taken, most of the toxic dose is eliminated within 2448 hr. Limb rigidity 2. Strychnine and its metabolites are excreted in the urine. Strychnine is metabolized by the liver to strychnine N-oxide and eliminated as hepatic metabolites. However, unintentional toxicity has occurred from exposure to certain Chinese and Cambodian herbal me… Strychnine is an odorless, colorless crystalline powder that is found in both naturally occurring alkaloid forms as well as commercially produced salts. The half life of strychnine is about 10 hours.
Treatment of Strychnine Poisoning in Dogs Decontamination is important in decreasing the duration and severity of signs. First-aid treatment should be aimed at keeping the dog as quiet as possible.
It is found in a treated, colored (green, pink, etc.) seed or pellet in a 0.5% concentration. Treatment may last up to three days in severe cases and in cases in which the dog can survive. Breathing difficulties, inability to breathe 6. Strychnine is very rapidly absorbed from the stomach, and can result in clinical signs within 15 minutes to 2 hours. Vomiting The parent compound is also eliminated in the urine. It is metabolized in the liver by microsomal enzymes. Treatment of strychnine poisoning involves an oral application of an activated charcoal infusion which serves to absorb any poison within the digestive tract that has not yet been absorbed into the blood. Controlling seizures and preventing asphyxiation are most important. Therefore, the best thing to do is get medical care as quickly as possible. The following are some of the symptoms of strychnine poisoning: 1. Dogs are more susceptible than cats. Recovery from strychnine exposure is possible with early hospital treatment. Contemporary use of strychnine is mainly limited to the eradication of unwanted gophers, moles, and other rodents. Treatment of Strychnine Poisoning in Dogs Since the poisoning from strychnine can occur rapidly, the veterinarian must be quick at performing treatment. Stiff muscles 3. Treatment of strychnine poisoning is usually successful but is dependent on getting the dog to a veterinarian before the heart and respiration are irreversibly affected.
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