Concanavalin A (ConA) injection into mice leads to immunomediated liver injury. II. Journal of Immunology, 119(3), 1163-1168. It is lyophilized powder from a solution containing buffer salts and NaCl. If you do not receive an email within 10 minutes, your email address may not be registered, This Con A product agglutinates 2% fresh human type A red blood cells in 0.01 M PBS, pH 6.8, with 0.1 mM calcium and … ".author = "Gershwin, {M. Eric} and Steinberg, {A. D.}".journal = "International Archives of Allergy and Immunology",International Archives of Allergy and Applied Immunology.Dive into the research topics of 'Effect of concanavalin A on immunologic abnormalities of New Zealand (NZB/W) mice'. By continuing you agree to the. 1 ConA has a high affinity toward the hepatic sinus, which results in activation of immune cells in the liver. This Concanavalin A product is highly purified and aseptically filled. (1976), Becker et al. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.AB - The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.UR - http://www.scopus.com/inward/record.url?scp=0016439223&partnerID=8YFLogxK,UR - http://www.scopus.com/inward/citedby.url?scp=0016439223&partnerID=8YFLogxK,JO - International Archives of Allergy and Immunology,JF - International Archives of Allergy and Immunology,"We use cookies to help provide and enhance our service and tailor content. The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. (1975), Reeke et al. Changes in synthesis, turnover and secretion, and in numbers of molecules on the surface of B cells after mitogenic stimulation.Response of human thymus‐derived (T) and non‐thymus‐derived (B) lymphocytes to mitogenic stimulation in vitro.Binding and redistribution of lectins on lymphocyte membrane.Action of dextran sulfate as a direct and general B cell mitogen.Effects of anti‐immunoglobulin sera on migration inhibition mediated by human lymphocytes.T cell recognition of cell‐surface antigens. Allen J. Norin, Karen Kato, Bernard S. Strauss, Binding of stimulated human peripheral blood lymphocytes to Sepharose-concanavalin A is not reversed by methyl-α-mannoside, Cellular Immunology, 10.1016/0008-8749(76)90143-X, 24, 1, (186-190), (1976). However, Con A cross‐linked at the bottom of tissue culture petri dishes could activate DNA synthesis in B cells. (1975). Antigen recognition is necessary yet not sufficient for triggering T cell‐mediated immunity.Direct triggering of B lymphocytes by insolubilized antigen.Hapten‐specific augmentation of the anti‐idiotype antibody response to hapten‐myeloma protein conjugates in mice.Differences in the redistribution of concanavalin A and wheat germ agglutinin binding sites on mouse neuroblastoma cells.Isolation and identification of the major concanavalin A binding glycoproteins from murine lymphocytes.Lectin-binding proteins from lentil seeds as mitogens for murine b lymphocytes.Early Biochemical Events in T-Lymphocyte Activation by Mitogens.Carbohydrate-Binding Sites of Plant Lectins.Development of optimal conditions for lymphokine production by chicken lymphocytes.Veterinary Immunology and Immunopathology.Wheat germ agglutinin inhibits nerve fiber growth and concanavalin a stimulates nerve fiber initiation in cultures of dorsal root ganglia neurons.Polyclonal activators in pulmonary immune disease.Correlation of Interferon Gamma Inducing Ability to Sugar Binding Specificities of Various Lectins.In vivo stimulation of nerve cells by phytohemagglutinin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. (a) Wild‐type (WT) and HBs‐Tg mice were intraperitoneally injected with IL‐23 (4 μg/mouse) or PBS at 2, … This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice Lingli Dong 1 Department of Hematology and Immunology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. It is composed of identical subunits of 237 amino acid residues (M.W. Gershwin, M. E., & Steinberg, A. D. (1975). II. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts. (1975), Cunningham et al. It has been widely used in the therapeutic studies of immune hepatitis. Ability of suppressor T cells to act on both B cells and amplifier T cells. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your username,If the address matches an existing account you will receive an email with instructions to retrieve your username,I have read and accept the Wiley Online Library Terms and Conditions of Use.Number of times cited according to CrossRef:Structure-function and application of plant lectins in disease biology and immunity.Vergleichende Untersuchungen an den Lymphocyten‐Subpopulationen von Rind und Schwein.Zentralblatt für Veterinärmedizin Reihe B.Interaction of Monomeric and Oligomeric Soybean Agglutinins with Pig Lymphocytes and Plasma Membranes.Stimulation of Irradiated Human Lymphocytes by Different Mitogens.International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine.The Effect of Human Spermatozoa on Antigen and Mitogen Induced Blastogenesis.International Journal of Quantum Chemistry.Increased porcine circovirus type 2 replication in porcine leukocytes in vitro and in vivo by concanavalin A stimulation.Mitogens as Probes for Immunocyte Regulation: Specific and Non‐Specific Suppression of B Cell Mitogenesis.Ciba Foundation Symposium 18 ‐ Immunopotentiation.Lipid A of Salmonella typhimurium Suppressed T-cell Mitogen-Induced Proliferation of Murine spleen Cells in the Presence of Macrophage.In Vivo Performance Evaluation of a Transdermal Near- Infrared Fluorescence Resonance Energy Transfer Affinity Sensor for Continuous Glucose Monitoring.Concanavalin A for in vivo glucose sensing: A biotoxicity review.Antibody Structure and Molecular Immunology.Characterization of Human Lymphocyte Surface Receptors for Mitogenic and Non‐mitogenic Substances.The Involvement of Activated Specific Suppressor T Cells in Maintenance of Transplantation Tolerance.The Role of Adherent Cells in the Immune Response.B Lymphocyte Activation and Lattice Formation.Role of Antigen Structure in the Discrimination between Tolerance and Immunity by B Cells.Avian B Lymphocyte Subpopulations Origins and Functional Capacities.Antikörperstruktur und molekulare Immunologie (Nobel‐Vortrag).Synthesis, Surface Deposition and Secretion of Immunoglobulin M in Bone Marrow‐Derived Lymphocytes Before and After Mitogenic Stimulation.Redistribution and Fate of Ig Complexes on Surface of B Lymphocytes: Functional Implications and Mechanisms.Elicitation of Selective T and B Lymphocyte Responses by Cell Surface Binding Ligands.Mitogens as Probes for Immunocyte Activation and Cellular Cooperation.Establishment of a Human Monoclonal Antibody to Hanganutziu‐Deicher Antigen as a Tumor‐associated Carbohydrate Antigen.The activation of cloned macrophages by concanavalin A for tumoricidal effect: Assessmetn of tumor cell cytotoxicity by a clonogenic assay.Interaction of lectins with human T lymphocytes mitogenic properties, inhibitory effects, binding to the cell membrane and to isolated surface glycopeptides.Concanavalin A is mitogenic for resident peritoneal macrophages.Down regulation in B lymphocytes: low dose signals.The requirement for tetravalency of soybean agglutinin for induction of mitogenic stimulation of lymphocytes.IgM in bone marrow‐derived lymphocytes.
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