0000015157 00000 n 0000013348 00000 n 0000055829 00000 n The signaling pathway of arachidonic acid-induced c-jun transcription was independent of protein kinase C activation and involved a tyrosine kinase-dependent process. 0000000016 00000 n 0000118458 00000 n 0000004833 00000 n 0000024552 00000 n 0000014967 00000 n Thus, arachidonic acid may act as a second messenger in mediating the effects of IL-1 and TNF-alpha in the activation of c-jun.Bone Marrow Transplantation Laboratory, Methodist Cancer Center, Methodist Hospital, Indianapolis, IN 46202, USA.Search for other works by this author on:Copyright © 1996 by The American Society of Hematology,Copyright ©2020 by American Society of Hematology,https://doi.org/10.1182/blood.V88.10.3792.bloodjournal88103792. 0000005851 00000 n 0000005117 00000 n The effect of arachidonic acid was specific, because extracts from stimulated cells failed to phosphorylate a mutated fusion protein in which serine 63 and 73 of c-jun were each substituted with leucine. 0000013515 00000 n [PMC free article] Kannagi R, Koizumi K, Hata-Tanoue S, Masuda T. Mobilization of arachidonic acid from phosphatidylethanolamine fraction to phosphatidylcholine fraction in platelets. 0000003989 00000 n MT Rizzo, C Carlo-Stella; Arachidonic acid mediates interleukin-1 and tumor necrosis factor-alpha- induced activation of the c-jun amino-terminal kinases in stromal cells.We have previously shown that arachidonic acid mediates interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)-induced transcription of c-jun. Arachidonic acid is a polyunsaturated fatty acid (PUFA) with 20 carbon atoms and four double bonds in the cis (Z) configuration. Arachidonic acid (AA) is converted by enzymes in an important metabolic pathway to produce molecules known collectively as eicosanoids, 20 carbon molecules with significant physiological and pathological functions in the human body. Incorporation and metabolism of [14C]-arachidonic acid in guinea-pig lungs. 0000005265 00000 n 0000106633 00000 n 0000119201 00000 n 0000024364 00000 n 0000063212 00000 n 0000004983 00000 n Das et al. 0000061052 00000 n 0000005398 00000 n %PDF-1.4 %���� 0000107731 00000 n 0000119900 00000 n Treatment of stromal cells with propyl gallate, a dual inhibitor of lipoxygenase and cyclooxygenase enzymes, did not affect the ability of arachidonic acid to induce JNK activation. 0000062497 00000 n Similar results were obtained when cells were challenged with IL-1 and TNF- alpha. 0000084316 00000 n 0000027890 00000 n 0000025091 00000 n Arachidonic acid induced JNK activation in a time- and dose-dependent manner that was not mimicked by saturated fatty acids such as palmitic acid or other unsaturated fatty acids from the n-3, n-6, or n-9 series. 0000118887 00000 n size the available information on the AA pathway involve-ment in COVID-19. 0000004699 00000 n 0000119757 00000 n 0000062153 00000 n 0000058712 00000 n suggested that AA can act as … 0000002800 00000 n 0000119323 00000 n 0000003456 00000 n 0000118530 00000 n These results are consistent with the hypothesis that the signal transduction pathway by which arachidonate stimulates c-jun transcription involves activation of the JNK cascade. The metabolism of arachidonic acid by either COX pathway or lipoxygenase (LOX) pathway generates eicosanoids, which have been implicated in the pathogenesis of a variety of human diseases, including cancer, and are considered important in tumor promotion, progression, and metastasis. Furthermore, arachidonic acid itself and not its cyclooxygenase or lipoxygenase metabolites is involved in stimulating JNK activity. 0000006270 00000 n The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation Philip Davies, Philip J. Bailey, Marvin M. Goldenberg, and Anthony W. Ford-Hutchinson Annual Review of Immunology SINGLE-STRANDED DNA BINDING PROTEINS REQUIRED FOR DNA … 0000009558 00000 n 0000012914 00000 n 0000061974 00000 n 0000021461 00000 n The signaling pathway of arachidonic acid-induced c-jun transcription was independent of protein kinase C activation and involved a tyrosine kinase-dependent process. 0000004417 00000 n Extracts from arachidonic acid-treated cells catalyzed phosphorylation of the c- jun fusion protein, indicating stimulation of JNK activity. 1979 Dec; 67 (4):519–526. 0000018301 00000 n 0000014776 00000 n 0000118757 00000 n 0000004551 00000 n Since the first double bond, with respect to the methyl end, is between carbon 6 and 7, it is an omega-6 or n-6 polyunsaturated fatty acid, and in shorthand notation is referred to as 20:4n-6. xref 0000083596 00000 n 0000058814 00000 n 0000002608 00000 n Furthermore, other lipids, such as diacylglycerol, phosphatidic acid, and C2-ceramide, failed to induce a significant increase in JNK activity. The present study was undertaken to further elucidate the signal transduction pathway of arachidonate-induced c-jun transcription. 0000106594 00000 n 0000060853 00000 n 0000119471 00000 n 0000004271 00000 n 0000030889 00000 n 184 0 obj <> endobj 0000107228 00000 n Br J Pharmacol. 0000119023 00000 n Arachidonic Acid Pathway. Moreover, ETYA (5,8,11,14-eicosate-traynoic acid), a nonmetabolizable arachidonate analogue, also induced JNK activation. 0000107582 00000 n 0000005544 00000 n 0000014381 00000 n 0000002836 00000 n 0000003817 00000 n 184 84 0000083635 00000 n 0000021651 00000 n 0000001976 00000 n 0000013885 00000 n 0000041454 00000 n 0000012494 00000 n We used a glutathione-S-transferase-c-jun fusion protein containing the aminoterminal domain of c-jun (residues 5 to 89) to explore the hypothesis that arachidonic acid stimulates c-jun amino-terminal kinase (JNK) activity in the murine stromal cell line +/+.1 LDA 11. 0000084182 00000 n Arachidonic acid is a polyunsaturated fatty acid produced by membrane phospholipids through phospholipase-A 2 (PLA 2) in inflammatory condition. Biochem Biophys Res Commun. 0000062681 00000 n 0000006373 00000 n 0000120043 00000 n trailer 0000107131 00000 n 0000033594 00000 n
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