This paper presents a review of 40 single and multi-person cases of fatal aconite poisoning. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Pure aconite 2 mg or aconite plant 1 g may cause death.Toxicity and death have resulted when the plant has been consumed accidentally, possibly mistaken for wild parsley, horseradish, or other herbs growing in the wild.Most incidents of aconite toxicity result from the wide variability in strength of home preparations in Asian countries.Aconitine's toxicity is characterized by a burning or tingling sensation of the lips, tongue, mouth, and throat almost immediately following ingestion.
The concentrations of jesaconitine in cardiac blood, urine, and kidney were 12.1 ng/ml, 993.0 ng/ml, and 114.2 ng/g, respectively. Ventricular tachyarrhythmias following Aconitum poisoning are rarely responsive to lidocaine, 20, 21 unlike in our case. Avoid use.Aconitine is highly toxic. Numbness of the throat and difficulty with speech may ensue. In addition to oral administration, external application is reported to cause toxic symptoms. Most cases of aconite poisoning have occurred in Japan and China.
Lakhvinder Cheema was murdered on 27 January 2009 in Southall, West London, by his former lover, Lakhvir Kaur Singh through the use of poison derived from the Aconitum ferox plant, which contains the highly toxic alkaloid pseudaconitine. If you do not receive an email within 10 minutes, your email address may not be registered, In severe cases of poisoning, aconite toxicity can lead to paralysis of the heart and respiratory system, causing suffocation and cardiac arrest. Even external application is reported to cause toxic symptoms.
Instead of a quick death, poisonings are often very painful and protracted, leading to much suffering for the victim before they pass away.
Victims of,Singh was convicted on 10 February 2010 of the murder of Lakhvinder Cheema and,"Curry poisoner Lakhvir Singh found guilty of murder","Curry poison killer Lakhvir Singh jailed for life","R v Lakhvir Kaur Singh (Central Criminal Court) February 2010",https://en.wikipedia.org/w/index.php?title=Murder_of_Lakhvinder_Cheema&oldid=978657453,January 2009 events in the United Kingdom,Pages using infobox person with unknown parameters,Articles with unsourced statements from January 2012,All articles with vague or ambiguous time,Vague or ambiguous time from January 2017,Creative Commons Attribution-ShareAlike License.
Aconite is a well-known toxic-plant containing Aconitum alkaloids such as aconitines, benzoylaconines, and aconins.
), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, 90127, Palermo, Italy.Use the link below to share a full-text version of this article with your friends and colleagues.Herbal medicines are recognized as therapeutic options in alternative and traditional Chinese medicine for several pathological conditions, although improper uses may be harmful. Toxicity mainly affects CNS, heart, and muscle tissues, primarily resulting in cardiovascular complications.A single dose of aconitine 0.6 mg/kg administered intraperitoneally to rabbits caused histopathologic damage to the myelin sheath of the visual pathway, spinal cord, and peripheral nerves.A review has summarized the toxicological mechanisms of Aconitum alkaloids, which include the following: (1) binding to voltage-dependent sodium channels inducing a hyperpolarized state, resulting in permanent activation of the channel; (2) modulation of neurotransmitter release and receptors, particularly norepinephrine and acetylcholine; (3) promotion of lipid peroxidation of the cardiac system, possibly causing cardiac arrhythmias; and (4) induction of cellular apoptosis in the heart, liver, and other organs.General supportive measures, including fluids for dehydration, intravenous pressor agents (eg, dobutamine, dopamine) for hypotension, and resuscitative measures when indicated, form the basis of aconite toxicity management.Evidence suggests that aconite may lose potency after undergoing certain manufacturing procedures; therefore, processed aconite may not have a toxicity profile similar to that of crude plant material.This information relates to an herbal, vitamin, mineral or other dietary supplement.
2012 Oct 10;222(1-3):1-3. doi: 10.1016/j.forsciint.2012.02.026.
Clinically important toxicity may develop following percutaneous absorption; even slight contact with the flowers can cause fingers to become numb.Aconitine is an alkaloid derived from various species of Aconitum.
Aconite has also been used in cases of suicide and homicide because of its high toxicity (9-11). Undoubtedly, educational campaigns and ethnic healthcare integration processes should be implemented to contain adverse events related to alternative medicine. Exclusion of acute neurological events was reached by a CT head scan, which did not reveal significant alterations.Deeper investigations on patient daily routine were then conducted, in order to identify possible causes underlying this impaired clinical status. Pure aconite 2 mg or aconite plant 1 g may cause death.Singh 1986. Data on the distribution of the Aconitum alkaloids in the body in cases of aconite poisoning is useful to elucidate various actions of aconite alkaloids.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.This site needs JavaScript to work properly. The cases involved 53 victims in mainland China described in 27 case …
Many species are used medicinally in China only after processing. Eleven and 13 patients, respectively, received kampo formulas including and excluding Aconiti tuber.
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